Evaluación de la vacuna combinada attenuvax-viruela en Chile
Evaluation of combined attenuvax-smallpox vaccine in Chile
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s.d., 1971
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Reactions to combined attenuvax-smallpox vaccine were studied, and were compared with those produced by each type of vaccine separately, in children from one to five years of age, controlled by maternal-child care centers under the National Health Service in Santiago, Chile. Combined freeze-dried and preblended attenuvax-smallpox vaccine and freeze-dried "Dryvax" smallpox vaccine were used. The combined vaccine was jet-injected, while the measles vaccine was administered in the form of subcutaneous injections, and the smallpox vaccine by the multipuncture technique
The new preblended and combined attenuvax-smallpox vaccine administered by jet injection produces general clinical reactions similar to or milder than those caused by each vaccine when administered separately
"Takes" were recorded in 96.9 per cent of children inoculated with the combined vaccine, which is an excellent result
To judge from the rise in titers in serological tests counts for both viruses in the cases inoculated, there was no evidence of interference between antigens. The conversion rate for each virus closely resembled that obtained when each vaccine was administered separately, and the geometric mean of the hemoagglutination inhibition titers was also very similar for the combined vaccine and for each vaccine administered separately
Revaccination against smallpox in children inoculated two months earlier with the ... (AU)
The new preblended and combined attenuvax-smallpox vaccine administered by jet injection produces general clinical reactions similar to or milder than those caused by each vaccine when administered separately
"Takes" were recorded in 96.9 per cent of children inoculated with the combined vaccine, which is an excellent result
To judge from the rise in titers in serological tests counts for both viruses in the cases inoculated, there was no evidence of interference between antigens. The conversion rate for each virus closely resembled that obtained when each vaccine was administered separately, and the geometric mean of the hemoagglutination inhibition titers was also very similar for the combined vaccine and for each vaccine administered separately
Revaccination against smallpox in children inoculated two months earlier with the ... (AU)
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Item Intradermal administration of measles vaccines(1994)The aim of the study reported here was to determine if bifurcated needles or multiple puncture cylinders would prove suitable for administation of measles vaccines. Children 9 to 11 months old in Sao Paulo, Brazil, were assigned to receive either Biken-Cam 70 (5 000 TCID 50/0.5 ml) or Edmonston-Zagreb (7 000 TCID 50/0.5 ml) measles vaccine intradermally with a bifurcated needle or a multiple puncture cylinder. These devices are usually used to administer smallpox of BCG vaccine. The volume of vaccine inoculated was aproximately 0.003 ml. Measles IgG antibodies were measured by enzyme-linked immunosorbent assay (ELISA) at the time of vaccination and 8 week later. The study participants were examined 14 days after inoculation for possible adverse reactions. Overall, the children's average age was 9.5 + 0.66 months at vaccination. None of the 45 recipiests of Biken-Cam vaccine responded serologically. The 49 Edmonston-Zagreb vaccine recipients immunized with the multiple puncture cylinder had a somewhat higher serologic response rate (35 percent) and mean concentration of measles antibodies ( 323 mIU/ml) than those 51 who received the same vaccine administered with the bifurcated needle (26 percent and 291 mIU/ml, respectively). The rates of reported symptoms after vaccination did not differ significantly among the groups. Overall, the low serologic response rates following intradermal immunization with the devices tested in this study indicate that this route of administration is not suitable for routine administration of standard-titer vaccinesItem Vacinação antivariólica em crianças menores de seis meses(s.d.)The author presents the results of smallpox vaccination of 220 children under six months of age and the follow-up of 200 vaccines, 47 of them only one month oldItem Respuesta a la tuberculina en escolares de Pacasmayo, Perú(1989)To shed some light on the controversy over the protective effect of BCG vaccine and the usefulness of the tuberculin test in countries with a high prevalence of tuberculosis, in September and October 1987 the test was administered to 440 primary school students in the province of Pacasmayo, Peru. The subjects, both vaccinated with BCG and unvaccinated, ranging from 6 to 10 years of age and coming from rural and urban areas with corresponding vaccination coverage of 55 and 60 per cent, were selected by cluster sampling. The tuberculin reaction was negative in 71 per cent of the vaccinated children and 83 per cent of the unvaccinated children, positive in 16 and 11 per cent, respectively, and inconclusive in the remaining subjects. The results suggest that BCG only prevents progression to the serious forms of the infection. The positive reaction indicates infection or reinfection with Mycobacterium tuberculosis regardless of vaccination status. A negative response in unvaccinated children almost always indicates the absence of infection. The inconclusive results in the unvaccinated children could be the result of a nonspecific allergy and, in the vaccinated children, of persistence of the change produced by M. tuberculosis. The percentage of infected schoolchildren was similar to that in other areas of the country with similar epidemiological characteristics. The tuberculin test appears to be especially important when more than five years have passed since vaccination (Au)Item Vacunación en masa contra el sarampión en Chile con la vacuna de virus atenuado de enders(s.d.)In view of the promising results of previous studies, a measles vaccination campaign with Enders attenuated virus vaccine (Edmonston B strain) was undertaken in Chile. The program was carried out in Santiago and in the southern provinces. Up to April 1964, 85,000 children under the age of five had been vaccinated. Between 10 and 12 per cent of the children vaccinated had postvaccinal variations, in particular eruptions or high fever. It was noted that there was a difference in the reactions produced by vaccines from different batches. There were 26 cases of postvaccinal complications but all quickly recovered. In addition, there were two cases of encephalitis but they also recovered. The epidemiological evaluation of the program was based on the observation of a group of 2,000 children vaccinated prior to 1 July 1965 who were compared with a control group. In the control group only cases of measles occurring after the above-mentioned date were taken into account. Whereas only seven cases of measles were reported in the vaccinated group, none of which were fatal, there were 464 cases in the control group, 25 of which were fatal. These results are an eloquent testimony of the value of mass measles vaccination with Enders attenuated virus vaccine (Edmonston B strain)Item Immunogenicity and safety of a tetravalent dengue vaccine in dengue-naïve adolescents in Mexico City(2021)[ABSTRACT]. Objective. To describe the immunogenicity and safety of a tetravalent dengue vaccine (TAK-003) in healthy adolescents living in Mexico City, an area considered non-endemic for dengue (NCT03341637). Methods. Participants aged 12–17 years were randomized 3:1 to receive two doses (Month 0 and Month 3) of TAK-003 or placebo. Immunogenicity was assessed by microneutralization assay of dengue neutralizing antibodies at baseline, Months 4 and 9. Solicited and unsolicited adverse events (AEs) were recorded after each vaccination. Serious (SAEs) and medically-attended AEs (MAAEs) were recorded throughout the study. Results. 400 adolescents were enrolled, 391 (97.8%) completed the study. Thirty-six (9%) were baseline seropositive to ≥1 serotypes (reciprocal titer ≥10). Geometric mean titers (GMTs) in baseline seronegative TAK-003 recipients were 328, 1743, 120, and 143 at Month 4, and 135, 741, 46, and 38 at Month 9 against DENV-1, -2, -3, and -4, respectively. Placebo GMTs remained <10. Tetravalent seropositivity rates in vaccine recipients were 99.6% and 85.8% at Months 4 and 9, respectively. One MAAE in each group was considered treatment-related (TAK-003: injection-site erythema, and placebo: pharyngitis). Conclusion. TAK-003 was immunogenic against all four serotypes and was well tolerated in dengue-naïve adolescents living in Mexico City.